The Effects of Emodin on the Expression of Cytokines and Functions of Leukocytes from Sprague-Dawley Rats

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 口腔衛生學系 > 期刊論文 > Item 310903500/1586

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/1586

题名:	The Effects of Emodin on the Expression of Cytokines and Functions of Leukocytes from Sprague-Dawley Rats
作者:	游富順;游春淑;(Jack Kai-Sheng Chan);郭秀滿;林景彬(Jing-Pin Lin);唐娜櫻;張永賢(Chang,Yung-Hsien);鍾景光(Jing-gung Chung)*
贡献者:	健康照護學院口腔衛生學系
关键词:	Emodin;cytokines;leukocyte function
日期:	2006-06
上传时间:	2009-08-19 17:00:27 (UTC+8)
摘要:	Emodin has been reported to induce apoptosis in many human cancer cell lines, although its effects on leukocyte functions in vitro have not been demonstrated. Therefore, the purpose of this study was to assess the effect of emodin on the phagocytosis of macrophages, the activity of natural killer cells and the expression of cytokines in leukocytes from Sprague-Dawley rats. Leukocytes, isolated from rats, were placed into culture plates for incubation with or without various concentrations of emodin for 1-6 hours and the functions of macrophages and natural killer cells were evaluated by flow cytometric analysis. The results indicated that emodin caused a decrease in phagocytosis of macrophages after treatment for up to 4 hours but 6-hour treatments led to an increase in the phagocytosis of macrophages. Further, emodin increased the activity of natural killer cells, both effects being dose-dependent. The levels of cytokines from the examined leukocytes were evaluated by ELISA and the results indicated that emodin increased the levels of IL-1β, and TNF-α, results which were confirmed
關聯:	IN VIVO 20(1):147~152
显示于类别:	[口腔衛生學系] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
	0Kb	Unknown	369	检视/开启

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....