Berberine Inhibits WEHI-3 Leukemia Cells In Vivo

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 口腔衛生學系 > 期刊論文 > Item 310903500/1585

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题名:	Berberine Inhibits WEHI-3 Leukemia Cells In Vivo
作者:	游富順;楊家欣(Yang Jai-Sing);林慧茹(Hui-Ju Lin);游春淑;譚思濰(Tan Tzu-Wei);(YUH-TZY LIN);(CHIN-CHUNG LIN);(HSU-FENG LU);鍾景光*
贡献者:	健康照護學院口腔衛生學系
关键词:	Berberine;WEHI-3 leukemia cells;BALB/c mice;cytotoxicity;apoptosis
日期:	2007-05
上传时间:	2009-08-19 17:00:26 (UTC+8)
摘要:	Berberine, an isoquinoline alkaloid, has a wide range of pharmacological effects including anticancer activities, yet the exact effects on leukemia in vivo are unknown. Our previous studies have demonstrated that berberine induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. In order to understand the berberine action against leukemia, the effect of berberine on WEHI-3 leukemia cells in vivo was studied. The results showed that Mac-3 and CD11b markers were reduced, indicating differentiation inhibition of the macrophages and granulocytes precursors. There was no affect on the CD14 marker but the CD19 marker that was indicating the promotion of the differentiation of the B-cells precursors. The weights of spleen samples from mice treated with berberine were found to be lower when compared to these from untreated animals.
關聯:	IN VIVO(21):407~412
显示于类别:	[口腔衛生學系] 期刊論文

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