維生素D抗氧化及DNA修復作用與前列腺癌的風險評估

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Title:	維生素D抗氧化及DNA修復作用與前列腺癌的風險評估
Other Titles:	The Antioxidant and DNA Repair Activities of Vitamin D and Prostate Cancer Risk
Authors:	鮑柏穎(Bo-Ying Bao)
Contributors:	藥學院藥學系
Date:	2009-07-31
Issue Date:	2009-09-01 16:30:33 (UTC+8)
Abstract:	癌變是一種涉及累積脫氧核糖核酸損傷，且多步驟的過程。生產過剩的氧化壓力，無論從內源性或外源性的來源，已證明和氧化誘導脫氧核糖核酸的損傷有關。很多證據還顯示，營養素，如維生素D，攝入的不足，可能增加基因的不穩定性。因此，我們假設缺乏維生素D 和氧化壓力防禦及脫氧核糖核酸損傷修補基因的多型性，可能會導致癌症發病率上升。此研究的具體目標是：1) 評估維生素D 的化學保護機制。 2) 評估維生素D 調控的氧化壓力防禦及脫氧核糖核酸損傷修補基因遺傳變異與前列腺癌的風險。研究維生素D 的化學保護機制和氧化壓力防禦及脫氧核糖核酸損傷修補基因的遺傳多型性，不僅可以讓我們準確地了解維生素D 和前列腺癌相互作用，也可以讓我們理解氧化壓力在前列腺癌變中扮演的分子機制。因此，這項研究的結果更可以提供針對前列腺癌的預防策略。 Carcinogenesis is a multistep process involving the accumulation of DNA damage. Overproduction of oxidative stress, through either endogenous or exogenous sources, has been linked to oxidant-induced DNA damage. Evidence also suggests that inadequate intakes of micronutrients, such as vitamin D, may be associated with increased genomic instability. Therefore, we propose that vitamin D deficiency in conjunction with polymorphisms in oxidative stress defense and DNA damage repair genes may lead to increased cancer risks. The specific aims of the current proposal are: 1) To evaluate the chemopreventive effects of vitamin D. 2) To estimate the association of common germline genetic variations in vitamin D-regulated oxidative stress defense/DNA damage repair genes and prostate cancer (PCa) risk. Investigation of the interactions between vitamin D and genetic polymorphisms in oxidative stress defense/DNA damage repair genes will not only more precisely decipher the role of vitamin D in PCa etiology, but also add to our understanding of the molecular mechanisms in association with oxidative stress involved in PCa. Additionally, the findings of this study might provide targeted PCa prevention strategies.
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