西藥對健康食品紅麴之安全性評估

CMUR > College of Pharmacy > School of Pharmacy/Master Degree Program, Ph. D program > Research reports > Item 310903500/13730

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Title:	西藥對健康食品紅麴之安全性評估
Other Titles:	Evaluating the Effect of Synthetic Drugs on the Safety of Health Food Red Yeast Rice (I)
Authors:	徐素蘭(Hsiu,Su-Lan);李珮端(Pei-Dawn Lee Chao);溫國慶(Wen,Kuo-Ching);侯鈺琪(Hou,Yu-Chi)
Contributors:	藥學院藥學系
Keywords:	紅麴;紅黴素;洛伐斯汀;Red Yeast Rice;erythromycin;lovastatin
Date:	2003-12-31
Issue Date:	2009-09-01 16:28:48 (UTC+8)
Abstract:	近年來紅麴中的主要成分被證實是西醫臨床上之降血脂處方藥lovastatin，使得宣稱具降血脂功能之紅麴倍受重視。Lovastin於體內會代謝為Lovastatin acid，由於lovastatin與lovastatin acid於體內主要經由腸或肝之代謝？CYP3A4代謝，若併服其他會抑制CYP3A4之藥物，可能會大幅增加此二成分之血中濃度而導致造成橫紋肌溶解症之副作用。本計畫擬建立lovastatin 、lovastatin acid 於紅麴中及血清中之定量方法，然後以大白鼠為模型，探討併服erythromycin對紅麴中lovastatin及lovastatin acid動力學行為之影響。血中濃度的數據分析擬利用WINNONLIN軟體計算動力學參數，並以paired Student t-test進行統計分析。期望藉此計畫了解併服erythromycin對紅麴動力學之影響，民眾服用健康食品以蔚為風尚，希望提供正確用藥資訊，避免因併服此些西藥而引起嚴重的藥物不良反應。 Comply with the higher living standard, ？HH？H？？overnutrition？HH？HH is a growing problem in Taiwan. Variety of healthy foods consisted of Red Yeast Rice are jumping on the market and have become the hot products for those who want to lower fat. In recent years, it has been proved that the major active constituent in Red Yeast Rice is lovastatin, which is clinically as a prescribed drug for lowering cholesterol. Lovastatine is largely hydrolyzed into lovastatin acid after oral dosing, and both constituents are then substantially metabolized by CYP3A4 in the intestine or liver. The coadministration of CYP3A4 inhibitors may markedly increase blood concentrations of lovastatine and lovastatin acid and thus might result in side effect like rhabdomyolysis. This study attempts to develop methods for the determination of lovastatin and lovastatin acid in Red Yeast Rice and in serum. In addition, the effect of erythromycin on the absorption and disposition of lovastatin and lovastatin acid in rats after coadministration with Red Yeast Rice will be investigated. The pharmacokinetic parameters of lovastatin and and lovastatin acid will be calculated using WINNONLIN. Paired Student？HH？HHs t- test will be used for the statistical analysis. The result could provide information for drug-health food interaction.
Appears in Collections:	[School of Pharmacy/Master Degree Program, Ph. D program] Research reports

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