Heroin abuse is a major public health concern, with individuals risked with blood-borne disease as hepatitis B, C and HIV infection. There are 1840 among 7044 HIV infection who were heroin abuse, and the rate is still increasing. As the investigation of CDC of USA, the most risk behavior related HIV is share injection needle and unsafe sexual behavior. The HIV infected patient had more prevalence of psychiatric disease as major depression and anxiety and impaired of cognitive function and difficulty on social and economic problems. There are the major concerns of prevention of HIV among heroin abuser on community. This is a 2-year proposal on study of prevalence of HIV for heroin abuse patients among hospital and community. We will enroll 120 (60 in hospital on 1st year, 60 in community) adult patients. All parts of this research will start after being approved by the Institution Review Board in study sites. Psychopathologic determinations (psychometric scores of Hamilton Rating Scale for Depression (HRSD), the 21-item Beck Depression Inventory (BDI), the 21-item Beck Anxiety Inventory (BAI), the Beck Suicide Scale (BSS), the 28-item WHO Quality of Life Scale (WHO-QOL-28) and the SCID(Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition) ), quantitative interview to illness attitude to HIV and heroin use will be obtained and every years. We looking forward to develop a HIV treatment model on hospital base and will extended to community. We also expected to have important result on the major journal.