A series selenopyrazde analogs of YC-1 and related compounds were synthesized and evaluated for their cytotoxicity. Among those tested compounds 1-benzyl-3-(2-hydroxymethyl-5-furyl)seleno[ 3,2-c]pyrazole (I-8) was the most promising agent which was evaluated for cytotoxicity activity against the NCI human cancer cell line panel. The results were analyzed computationally and presented as dose-response curves, at five different concentration between 10-4 and 10-6 M. GI50、TGI and IC50 values were calculated and the corresponding mean graph was obtained. The results showed than compound I-8 was active against most tested cancer cell lines with mean growth midpoint (MG-MID) for log GI50 equal to -4.68. The highest potency was found against NCI-H226 (log GI50, -6.50) and A-498 (log GI50, -6.79). Based on the above finding, compound I-8 was idenfified in this study as a promising anti-lung cancer and anti-renal cancer drug candidate.
