Fitting Logistic Regression Models using Contaminated Case-Control data

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Title:	Fitting Logistic Regression Models using Contaminated Case-Control data
Authors:	鄭光甫;(Chen L. C.)
Contributors:	公共衛生學院公共衛生學系
Keywords:	Case–control data;Contamination;Logistic regression;Maximum likelihood;Misclassification
Date:	2006-12
Issue Date:	2009-08-19 16:48:13 (UTC+8)
Abstract:	Errors in measurement frequently occur in observing responses. If case–control data are based on certain reported responses, which may not be the true responses, then we have contaminated case–control data. In this paper, we first show that the ordinary logistic regression analysis based on contaminated case–control data can lead to very serious biased conclusions. This can be concluded from the results of a theoretical argument, one example, and two simulation studies. We next derive the semiparametric maximum likelihood estimate (MLE) of the risk parameter of a logistic regression model when there is a validation subsample. The asymptotic normality of the semiparametric MLE will be shown along with consistent estimate of asymptotic variance. Our example and two simulation studies show these estimates to have reasonable performance under finite sample situations.
Relation:	JOURNAL OF STATISTICAL PLANNING AND INFERENCE 136(126):4147~4160
Appears in Collections:	[Department of Public Health] Journal articles

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