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    題名: 二種中藥及五種本土植物其活性之研究
    作者: 郭悅雄
    貢獻者: 藥學院中國藥學研究所;中國附醫院長室
    日期: 2009-07-31
    上傳時間: 2009-09-01 16:07:40 (UTC+8)
    摘要: 從小花咸豐草之全草分離二個新的化合物為含peroxide之葉綠素,此植物為民間常用的中草藥;羅氏鹽福木之根部亦是民間用藥,其根部分出二種新的配糖體化合物,以及三個三萜類;由功能性食物薏苡仁之麩皮找出可以抑制肺與大腸癌細胞之生長物;雙面刺在民間用藥是為減緩牙痛及喉嚨痛,由此植物之根部分出五種新的植物鹼;六種新的四碳內酯從屏東木薑子之莖皮分出,而其中一已知化合物具有抑制三種癌細胞之生成活性;恆春福木被用為傳統中藥,此植物之根部被研究有抗氧化活性,除了分出26種化合物,另外有一新骨架化合物被確認;樟芝子實體分出6種新化合物,其中4種新化合物具有抗發炎活性;台灣杉之材部是好的建材,由其莖部找出7種雙萜類新化合物;疏花魚藤可當殺草與殺蟲劑,由其根部找到7種新化合物。

    Two new pheophytins, with peroxide functionalities on ring E, were isolated from Bidens pilosa. This plant is a popular Taiwanese folk medicin. The roots of Rhus javanica was used as herbal medicine. Two new phenol glycosides and three new triterpenes were isolated and established their structures. . Assay-guided islation from the bran of Coix lachrymal- jobil var. ma-yuen give four new lactam compouds, which showed anti-proliferative effect of lung and colon cancer cells. The stems and leaves have been used as folk medicines to relieve toothache and sore throat. Six new butanolides were isolated from the stem bark of Litsea akoensis. One known compound exhibited cytotoxic activity. Garcinia multiflora, a dioecious tree, is used as a traditional Chinese medicine. Except twenty-six compounds, one novel skeleton compound, garcinial one were isolated and elucidated, Six new compounds were isolated from the fruiting bodies of Antrodia camphorate. Four of six compounds possessed anti- inflummatory activities. Taiwania cryptomerioides is a good and important building material. We reinvestigated its bark, and seven new diterpenes were isolated and identified. The extract of the root of the Derris laxiflora was used traditionally as an insecticide and piscicide. Seven new compounds were isolated from its root’’s extractions.
    顯示於類別:[中國藥學研究所(已停用)] 研究計畫

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