Retrospective analysis of case-control studies when the population is in Hardy-Weinberg equilibrium

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 公共衛生學院 > 公共衛生學系暨碩博班 > 期刊論文 > Item 310903500/1282

請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/1282

題名:	Retrospective analysis of case-control studies when the population is in Hardy-Weinberg equilibrium
作者:	鄭光甫;(W. J. Lin)
貢獻者:	公共衛生學院公共衛生學系
關鍵詞:	case-control study;Hardy-Weinberg equilibrium;logistic regression;maximum likelihood estimate;odds ratio;retrospective model
日期:	2005-11
上傳時間:	2009-08-19 16:48:11 (UTC+8)
摘要:	Association analysis of genetic polymorphisms has been mostly performed in a case-control setting in connection with the traditional logistic regression analysis. However, in a case-control study, subjects are recruited according to their disease status and their past exposures are determined. Thus the natural model for making inference is the retrospective model. In this paper, we discuss some retrospective models and give maximum likelihood estimators of exposure effects and estimators of asymptotic variances, when the frequency distribution of exposures in controls contains information about the parameters of interest. Two situations about the control population are considered in this paper: (a) the control population or its subpopulations are in Hardy-Weinberg equilibrium; and (b) genetic and environmental factors are independent in the control population. Using the concept of asymptotic relative efficiency, we shall show the precision advantages of such retrospective analysis over the traditional prospective analysis. Maximum likelihood estimates and variance estimates under retrospective models are simple in computation and thus can be applied in many practical applications. We present one real example to illustrate our methods.
關聯:	STATISTICS IN MEDICINE 24(21):3289~3310
顯示於類別:	[公共衛生學系暨碩博班] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	542	檢視/開啟

在CMUR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....