Basic reproduction number for HIV model incorporating commercial sex and behavior change

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Title:	Basic reproduction number for HIV model incorporating commercial sex and behavior change
Authors:	謝英恒*;(Yun-Shih Wang)
Contributors:	公共衛生學院公共衛生學系
Keywords:	HIV/AIDS;Commercial sex workers;Basic reproduction number;Thailand;Behavior change;Asymptotic stability
Date:	2006-05
Issue Date:	2009-08-19 16:48:08 (UTC+8)
Abstract:	The basic reproduction number is obtained for an HIV epidemic model incorporating direct and indirect commercial sex as well as behavior change by the female commercial sex workers (CSWs) and their male customers in response to the proliferation of the disease in the community. A recent result by van den Driessche P., and Watmough J. (Math. Biosci. 180:29–48, 2002) is utilized to compute the threshold parameters for the local asymptotic stability of the Disease-Free Equilibrium (DFE), by considering the transfers in and out of the infective classes. Numerical examples are used to describe the uniqueness and global properties of the endemic equilibrium when DFE is unstable. Biological interpretation of the results obtained in this work is discussed, as are the implications of our results for the design of public health policies such as targeting strategy to target intervention and control measures toward specific high-risk population groups in order to reduce infections. We show that targeting any one sector of the commercial sex alone for prevention will be difficult to have a decided effect on eradicating the epidemic. However, if the aim of the targeted intervention policy is not eradication of the epidemic but decrease in HIV incidence of a particular high-risk group, then concentrated targeting strategy could be sufficient, if properly implemented. This work also demonstrates the usefulness of the theorem of van den Driessche and Watmough (Math. Biosci. 180:29–48, 2002) in obtaining threshold parameters for complicated infectious diseases models.
Relation:	BULLETIN OF MATHEMATICAL BIOLOGY 68(3):551~575
Appears in Collections:	[Department of Public Health] Journal articles

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