國內沙門氏桿菌的Fluoroquinolone抗藥性產生之分子機制與流行病學研究

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Title:	國內沙門氏桿菌的Fluoroquinolone抗藥性產生之分子機制與流行病學研究
Other Titles:	Molecular Mechanisms and Epidemiological Research of Fluoroquinolone Resistance among Salmonella in Taiwan
Authors:	徐媛曼(Hsu,Yuan-Man);張照勤(Chang,Chao-Chin)
Contributors:	醫學院生物科技學系
Date:	2004-12-31
Issue Date:	2009-09-01 15:51:42 (UTC+8)
Abstract:	隨著分子生物學的發展，應用PFGE進行菌株分型，以確定相同血清型菌株間之種源關係，確認主要流行菌株，已被廣泛應用於流行病學的調查與研究上；再者，沙門氏菌很容易自外界獲得帶有抗藥基因的質體，因而改變其抗藥性圖譜，藉以分析其質體圖譜，可以探討抗藥性基因之來源。本計畫將調查由動物分離出的沙門氏桿菌之抗藥性及抗藥機制，深入了解其抗藥性情況，並進一步評估感染動物及感染人類的沙門氏桿菌其抗藥基因互相傳遞的可能性。 Using PFGE, a well-developed molecular biology method, to identify bacteria subtypes and confirm major prevalent strains has been applied widely in epidemiological investigation and research. Furthermore, it is easy for Salmonella to change their antibiotic resistance profiles by obtaining plasmids carrying antibiotic resistance genes. Thus, by analyzing plasmid profiles, the sources of antibiotic resistance gene can be determined. We will investigate the antibiotic resistance profiles and mechanisms of Salmonella-human and -animal isolates, in order to understand the Salmonella population response to antibiotics and further estimate the possibility of exchange antibiotic genes between human and animals.
Appears in Collections:	[Department of Biological Science and Technology] Research reports

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