The central serotonergic system mediates the analgesic effect of electroacupuncture on ZUSANLI (ST36) acupoints

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Title:	The central serotonergic system mediates the analgesic effect of electroacupuncture on ZUSANLI (ST36) acupoints
Authors:	張芳嘉(Fang-Chia Chang);蔡輝彥(Huei-Yann Tsai);游明謙(Yu MC);尹珮璐(Yi PL);林昭庚(Jaung-Geng Lin)*
Contributors:	中醫學院針灸研究所
Keywords:	Electroacupuncture;Analgesia;Serotonin
Date:	2004
Issue Date:	2009-08-19 16:44:38 (UTC+8)
Abstract:	Evidence in the past decade indicates that the mechanisms of anti-nociception of electroacupuncture (EAc) involve actions of neuropeptides (i.e., enkephalin and endorphin) and monoamines (i.e., serotonin and norepinephrine) in the central nervous system. Our present results using a subcutaneous injection of formalin to test pain sensation in mice provide further understanding of the involvement of serotonin in the actions of EAc-induced analgesia. Our observations show that (1) EAc at three different frequencies (2, 10 and 100 Hz) elicited an anti-nociceptive effect as determined by behavioral observations of reduced hindpaw licking; (2) exogenously intracerebroventricular administration of 5-hydroxytryptamine (5-HT) exhibited an analgesic effect, which partially mimicked the analgesic actions of EAc; (3) the anti-nociception of EAc at different frequencies was attenuated after reduced biosynthesis of serotonin by the administration of the tryptophan hydroxylase inhibitor, p-chlorophenylalanine, and (4) the 5-HT1A and 5-HT3 receptor antagonists, pindobind-5-HT1A and LY-278584, respectively, blocked three different frequencies of EAc-induced analgesic effects, but the anti-nociceptive effect of 100 Hz EAc was potentiated by the 5-HT2 receptor antagonist, ketanserin. These observations suggest that 5-HT1A and 5-HT3 receptors partially mediate the analgesic effects of EAc, but that the 5-HT2 receptor is conversely involved in the nociceptive response.
Relation:	JOURNAL OF BIOMEDICAL SCIENCE 11(2):179~185
Appears in Collections:	[Graduate Institute of Acupuncture Science] Journal articles

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