The radiophotoluminescent glass dosimeter (GD) was developed in the late 1950s while the reading technology was not sensitive enough to measure the low radiation dose and glass element sensitivity to radiation was also quite low. In recent years, the development of the pulsed UV laser excitation method which had high measurement accuracy was applied to the GD. In comparison with the thermoluminescent dosimeter, the advantages of the radiophotoluminescent glass dosimeter are good reproducibility of readout values, long stability, low energy dependence, better dose linearity and capability of repeatable readouts. There advantages were verified from our pilot study. This project is followed by the previous grant, the development of a new ionizing radiation glass dosimeter system. (NSC94-2314-B-010-034 and NSC 95-2314-B-010-015) In this project, we will (1) develop the new compound GD, (2) to study the principle of radiation measurement, (3) develop the new compound GD readout system and use this GD system to measure the clinical radiation dose. This study can not only establish our own radiophotoluminescent glass dosimeter system but also verify the variety of clinical radiation therapy dose that can ensure the accuracy of the irradiation dose and improve the quality of life after treatment. Glass dosimeter system is most available for personal monitoring, environmental monitoring and clinical application with high accuracy. It could be one of the most important radiation dose measurement instruments in the near future. Therefore, the development the novel compound and application of radiophotoluminescent glass dosimeter system will be very necessary.