In Taiwan, the rate of drug abuse criminal had grown 96.8% from 1991 to 2000. On the other hand, the average recurrence rate of treatment for drug abuser was 33.7% between 1998 and 2000. Drug abuse is now one of the most serious social problems. Therefore, how to effectively treat drug abuser becomes urgent issue for policy makers and health care providers. To treat drug abuse, several treatment modalities have been developed during past several decades. For treating drug abuse, three major treatment models are developed by Tsao-Tun Psychiatric Center, Taipei City Psychiatric Hospital respectively. The debate regarding which model is the most effectiveness continues. In this study, we will perform a formal cost-effectiveness analysis. For each model, outcome is based on QALYs improved and cost will be determined for hospital stay, direct and indirect cost relating treating drug abuse and loss of productivity. Our research is a prospective study. Subjects will be sampled from three major psychiatric hospitals in Taiwan. Three questionnaires including Addiction Severity Index (ASI), Short Form-36 (SF-36), Personality Questionnaire and hospital financial tables will be utilized to collect data. Multiple regression is used to identify the risk factors of treatment outcome.