Urinary β2- microglobulin Concentration and Neonatal Complications in Premature Infants

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Title:	Urinary β2- microglobulin Concentration and Neonatal Complications in Premature Infants
Other Titles:	尿液中β2- microglobulin 濃度與早產兒在新生兒期併發症之相關
Authors:	邱曉郁(Hsiao-Yu Chiu);蘇百弘(Bai-Horng Su);林鴻志(Hung-Chih Lin);林國瑞(Kuo-Juei Lin)
Contributors:	中國醫藥大學：醫學研究所碩士班
Keywords:	尿中β2-microglobulin;新生兒併發症;胎兒發炎反應;早產兒;Beta2-microglobulin, Fetal inflammatory response;Neonatal complications;Premature infant
Date:	2006-12
Issue Date:	2009-08-13 14:50:49 (UTC+8)
Abstract:	Objectives. To investigate the correlations between the elevated urinary β2-MG and the risk of development of neonatal complications. Methods. Seventy-five very low birth weight (<1500 g) premature infants were enrolled. Urinary β2-MG was measured with immunometric assay within 48 hours and at 28 days of age. Simultaneous urinary creatinine (Cr) was measured and used for the normalization of β2-MG excretion. Results. The mortality rate was 8% (6/75). Multivariate logistic regression analysis showed that there were positive association of elevated urinary β2-MG with periventricular leukomalacia (PVL) (OR 1.25, 95% CI 1.02-1.63 for 48 hrs; OR 1.18, 95% CI 1.09-1.42 for 28 days ), necrotizing enterocolitis (NEC) (OR 1.12, 95% CI 1.02-1.24 for 48 hrs; OR 1.32, 95% CI 1.06-1.84 for 28 days ), and chronic lung disease (CLD) (OR 1.92, 95% CI 1.24-2.13 for 48 hrs; OR 1.61, 95% CI 1.39-1.94 for 28 days ). No similar association was found in respiratory distress syndrome, symptomatic PDA, pulmonary hemorrhage, intraventricular hemorrhage, sepsis or retinopathy of prematurity. Conclusions. Urinary β2-MG was significantly higher at early life and sustained higher thereafter at least until 28 days of age in premature infants who developed PVL, NEC or CLD than in those who did not.
Appears in Collections:	[Graduate Institute of Medical Science] Theses & dissertations

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