Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of I kappa B kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia

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Title:	Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of I kappa B kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia
Authors:	Chen, JC;Ho, FM;Chao, PDL;Chen, CP;Jeng, KCG;Hsu, HB;Lee, ST;Wu, WT;Lin, WW
Contributors:	藥學院藥學系;Natl Taiwan Univ, Coll Med, Dept Pharmacol, Taipei, Taiwan;Tao Yuan Gen Hosp, Dept Hlth & Execut Yuan, Dept Internal Med, Tao Yuan, Taiwan;China Med Univ, Dept Pharm, Taichung, Taiwan;Taichung Vet Gen Hosp, Dept Educ & Res, Taichung, Taiwan;China Med Univ, Dept Internal Med, Taichung, Taiwan;Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
Date:	2005
Issue Date:	2010-09-24 18:56:06 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	In a case - control study in a veterans hospital in Taiwan, we compared 237 histology-confirmed prostate carcinoma cases with 481 controls, frequency matched by age, for their consumption of vegetarian food, namely soybean products, rice, wheat protein and other vegetables. The multivariable logistic regression analysis showed a significant association with such food ( odds ratio (OR) = 0.67, 95% confidence interval (CI) = 0.47, 0.94). This beneficial effect presented for men with body mass index (BMI) <= 25 kgm(-2) (OR = 0.50, 95% CI = 0.32, 0.76) but not for men with greater BMI. The OR of prostate carcinoma for men with BMI <= 25 kgm(-2) was 1.74 ( 95% CI 1.21, 2.51), compared with men with higher BMI (>25 kg m(-2)). Other significant risk factors associated with the disease included higher income (OR = 2.40, 95% CI = 1.07, 5.42), physical activity (OR = 1.75, 95% CI = 1.08, 2.83), being married (OR = 2.49, 95% CI = 1.40, 4.43) and coffee consumption (OR = 1.88, 95% CI = 1.07, 3.30). Stratified analysis also showed that the consumption of fish/shellfish had an adverse association for men with higher BMI. This study suggests that the intake of the low fat local vegetarian food has a protective effect against prostate carcinoma for thin men in this study population.
Relation:	EUROPEAN JOURNAL OF PHARMACOLOGY 521(1月3日):9-20
Appears in Collections:	[School of Pharmacy/Master Degree Program, Ph. D program] Journal articles

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