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http://ir.cmu.edu.tw/ir/handle/310903500/31003
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| 題名: | YC-1[3-(5 '-hydroxymethyl-2 '-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models |
| 作者: | Pan, SL;Guh, JH;Peng, CY;Wang, SW;Chang, YL;Cheng, FC;Chang, JH;Kuo, SC;Lee, FY;Teng, CM |
| 貢獻者: | 藥學院藥化所;Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan;Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei, Taiwan;China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan;MDS Pharma Serv, Taipei, Taiwan;Yung Shin Pharmaceut Ind Co Ltd, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 15:09:30 (UTC+8) |
| 出版者: | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS |
| 摘要: | The emergence of ciprofloxacin-resistant Salmonella enterica serovar Choleraesuis in recent years has become an important public health issue in Taiwan. The resistant strains that cause human infections are considered to be from pigs. In this study, we characterized 157 swine and 42 human Salmonella serovar Choleraesuis isolates by pulsed-field gel electrophoresis (PFGE) and drug susceptibility testing to investigate the epiderniologic relationship among the isolates. By PFGE analyses, two major clusters (clusters GA and GB) were identified. Isolates in cluster GA were of both human and swine origins, while those in cluster GB were from pigs only. Among the various genotypes identified, genotype gt-la was the most prevalent, which was found in 71% (30 of 42) and 48% (76 of 157) of human and swine isolates, respectively. The susceptibility tests for the 106 gt-la isolates identified 44 susceptibility profiles and showed that 73% of human isolates and 34% of swine isolates were resistant to three fluoroquinolones (ciproffoxacin, enrofloxacin, and norfloxacin). Our findings indicate that a clonal group of Salmonella serovar Choleraesuis may have been circulating in human and swine populations in Taiwan for years and that the fluoroquinolone-resistant Salmonella serovar Choleraesuis strains most likely evolved from a gt-la clone that emerged in 2000 and that then caused widespread infections in humans and pigs. Nevertheless, it is still debatable whether those Salmonella infections in humans are caused by isolates derived from pigs, on the basis of the higher fluoroquinolone and other antimicrobial resistance percentages in human isolates than in pig isolates. |
| 關聯: | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 314(1):35-42 |
| 顯示於類別: | [藥物化學研究所] 期刊論文
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