Determination and disposition kinetics of phellamurin metabolites in rat brain

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Title:	Determination and disposition kinetics of phellamurin metabolites in rat brain
Authors:	Chen, HY;Wu, TS;Hou, YC;Kuo, SC;Chao, PDL
Contributors:	藥學院藥化所;China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan;Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan;Jen Te Jr Coll Med Nursing & Management, Miaoli, Taiwan;China Med Coll, Dept Pharm, Taichung 404, Taiwan
Date:	2001
Issue Date:	2010-09-24 15:07:59 (UTC+8)
Publisher:	NATL LABORATORIES FOODS DRUGS
Abstract:	Baicalin, baicalein and wogonin are bioactive flavonoids Of Scutellariae Radix. In order to compare the contents of baicalin, baicalein and wogonin between traditional decoction and commercial,extract, ten crude drugs and ten commercial extracts of Scutellariae Radix were purchased from the market. High performance liquid chromatographic method was used for simultaneous assay of these flavonoid constituents. The separation was performed on an Inertsil ODS-2 column with acetonitrile - 0.005% phosphoric acid (36:64, v/v) as mobile phase at a flow-rate of 1.0 mL/min and detection at 270 nm, and ethyl paraben was used as the internal standard. This method is applicable for the routine quality control of the crude drug and commercial extract of Scutellariae Radix. The results indicated that the contents of baicalin, baicalein and wogonin in traditional decoctions of each gram of Scutellariae Radix were 62.7 +/- 4.6 mg, 5.5 +/- 0.2 mg and 1.7 +/- 0.1 mg, whereas those in each gram of commercial extracts were 82.3 +/- 8.5 mg, 15.0 +/- 2.0 mg and 5.3 +/- 0.5 mg, respectively. The suggested daily doses of crude drug and commercial extract of Scutellariae Radix are 3.0 - 9.0 g and 0.4 - 9.0 g, respectively. Based on our results, the contents of baicalin, baicalein and wogonin in the maximum daily doses for traditional decoctions of Scutellariae Radix were 564.7 +/- 41.7 mg, 49.7 +/- 1.9 mg and 15.6 +/- 1.0 mg, whereas those for commercial extracts were 241.9 +/- 41.1 mg, 53.7 +/- 16.4 mg and 17.9 +/- 4.6 mg, respectively.
Relation:	JOURNAL OF FOOD AND DRUG ANALYSIS 9(3):127-131
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Journal articles

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