Inhibition of platelet function by A02131-1, a novel inhibitor of cGMP-specific phosphodiesterase, in vitro and in vivo

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 藥物化學研究所 > 期刊論文 > Item 310903500/30916

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题名:	Inhibition of platelet function by A02131-1, a novel inhibitor of cGMP-specific phosphodiesterase, in vitro and in vivo
作者:	Yu, SM;Tsai, SY;Kuo, SC;Ou, JT
贡献者:	藥學院藥化所;CHANG GUNG COLL MED & TECHNOL,DEPT MICROBIOL & IMMUNOL,TAYUAN,TAIWAN;CHINA MED COLL,GRAD INST PHARMACEUT CHEM,TAICHUNG,TAIWAN
日期:	1996
上传时间:	2010-09-24 15:06:14 (UTC+8)
出版者:	W B SAUNDERS CO
摘要:	Two cases of lead poisoning, caused by the Chinese herbal medicine Cordyceps, were reported to the Department of Health in a laboratory-based blood lead surveillance program, Such unusual cases of lead poisoning have not been previously reported, These two patients took Cordyceps herbal medicine for treatment of underlying diseases, Loss of appetite and anemic signs of lead poisoning were manifested in one patient with a blood lead level of 130 mu g/dl, while the other patient was asymptomatic with a blood lead level of 46 mu g/dl. The lead content in the Cordyceps powder was found to be as high as 20 000 ppm. After cessation of intake in the asymptomatic patient, and cessation of intake and treatment with chelating agents in the symptomatic patient, the blood lead levels returned to normal range, This report raises concerns about lead poisoning from unusual herbal medicine worldwide.
關聯:	BLOOD 87(9):3758-3767
显示于类别:	[藥物化學研究所] 期刊論文

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