Effects of ellagic acid by oral administration on distribution and metabolism of 2-aminofluorene in Sprague-Dawley rats

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Title:	Effects of ellagic acid by oral administration on distribution and metabolism of 2-aminofluorene in Sprague-Dawley rats
Authors:	Ho, CC;Lai, YS;Wang, DY;Chen, YS;Lee, JH;Tang, NI;Chung, JG
Contributors:	醫學院醫學系微生物學科;China Med Univ, Dept Microbiol, Taichung 404, Taiwan;China Med Univ, Sch Chinese Med, Taichung 404, Taiwan;China Med Univ, Dept Nutr, Taichung 404, Taiwan;Chungtai Inst Hlth Sci & Technol, Dept Nursing, Taichung 40605, Taiwan;Chung Shan Med Univ, Hosp & Med Coll, Dept Pathol, Taichung 408, Taiwan;China Med Univ Hosp, Dept Orthopaed, Taichung, Taiwan;China Med Univ Hosp, Dept Surg, Taichung, Taiwan
Date:	2005
Issue Date:	2010-09-24 15:03:09 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	It is well documented that N-acetyltransferase (NAT) plays a key role in the N-acetylation of arylamine compounds. Ellagic acid was demonstrated to elicit dosedependent bacteriostatic activity and inhibition of N-acetylation of 2-aminofluorene (AF). N-acetylation of AF in S. aureus was determined by high preformance liquid chromatography. The apparent values of Km and Vmax of NAT were decreased after co-treatment with 0.5 mM ellagic acid in the cytosol of S. aureus. PCR also indicated that ellagic acid inhibited NAT gene expression (NAT mRNA) in S. aureus.
Relation:	IN VIVO 19(1):143-156
Appears in Collections:	[School of Medicine] Journal articles

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