Quercetin glucuronides inhibited 2-aminofluorene acetylation in human acute myeloid HL-60 leukemia cells

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Title:	Quercetin glucuronides inhibited 2-aminofluorene acetylation in human acute myeloid HL-60 leukemia cells
Authors:	Kuo, HM;Ho, HJ;Chao, PDL;Chung, JG
Contributors:	醫學院醫學系寄生蟲學科;China Med Coll, Dept Parasitol, Taichung, Taiwan;China Med Coll, Dept Pharm, Taichung, Taiwan;China Med Coll, Dept Microbiol, Taichung, Taiwan;China Med Coll, Grad Inst Chinese Phamaceut Sci, Taichung, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:59:05 (UTC+8)
Publisher:	URBAN & FISCHER VERLAG
Abstract:	The purpose of this study was to evaluate the markers' clinical usefulness for early prediction of recurrence, by serial and simultaneous measurements of serum cytokeratin fragment 19 (CYFRA 21-1), before and after surgery on patients with non-small cell lung cancers (NSCLC). The 48 patients enrolled in this study had adenocarcinoma of the lung (adenoCa) (including 24 patients with recurrence and 24 patients without recurrence I year after surgery) and 48 patients with squamous cell carcinoma of the lung (SCC) (including 24 cases with recurrence and 24 without recurrence I year after surgery). Serial serum levels of CYFRA 21-1 were measured before the operation and I week, I month, 3 months, 6 months, 9 months, and 12 months after surgery for the early detection of recurrence. The results revealed that (1) the mean serum values of CYFRA 21-1 were significantly higher beginning at I month after surgery in the 24 patients with recurrent adenoCa compared with the 24 patients without recurrent adenoCa, (2) mean serum values of CYFRA 21-1 were significantly higher beginning at I month after surgery in 24 patients with recurrent SCC when compared with 24 patients without recurrent SCC, and (3) mean serum values of CYFRA 21-1 were significantly higher beginning at I month after operation in the total 48 patients with recurrent NSCLC when compared with 48 patients without recurrent NSCLC. We conclude that CYFRA 21-1 is not a good marker for early prediction of NSCLC recurrence including adenoCa and SCC after surgery.
Relation:	PHYTOMEDICINE 9(7):625-631
Appears in Collections:	[School of Medicine] Journal articles

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