Expression of Fas ligand in patients with evident skull base involvement of nasopharyngeal carcinoma

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30532

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题名:	Expression of Fas ligand in patients with evident skull base involvement of nasopharyngeal carcinoma
作者:	Tsai, MH;Chow, KC;Lin, TY;Yeh, SP;Hsueh, CT;Chi, KH
贡献者:	附設醫院醫研部;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan;China Med Coll Hosp, Dept Otolaryngol, Taichung 404, Taiwan;China Med Coll Hosp, Hematol Oncol Sect, Dept Med, Taichung 404, Taiwan;China Med Coll, Inst Med Res, Taichung, Taiwan;Vet Gen Hosp, Ctr Canc, Taipei, Taiwan;China Med Coll Hosp, Dept Pathol, Taichung 404, Taiwan
日期:	2002
上传时间:	2010-09-24 14:57:10 (UTC+8)
出版者:	PROFESSOR D A SPANDIDOS
摘要:	The ability of technetium-99m tetrofosmin (Tc-TF) scan to predict chemotherapy response in malignant lymphomas (ML) was compared with the predictive ability of P-glycoprotein (Pgp) and multidrug resistance related protein (MRP) expression. Before chemotherapy, 25 ML patients were enrolled in this study. Scans were performed 10 min after intravenous injection of Tc-TF. Immunohistochemical analyses were performed on ML specimen sections to evaluate Pgp and MRP expression. Chemotherapy response was evaluated in the first 1-2 years after completion of chemotherapy. Based on Tc-TF scan results, the mean tumor-to-background (T/B) ratio of the 15 patients with good response (3.23 +/- 0.56) was significantly higher than that of the 10 patients with poor response (1.18 +/- 0.11). All 15 patients with good response had positive Tc-TF scan results but negative Pgp and MRP expression. All 10 patients with poor response had negative Tc-TF scan results but positive Pgp or MRP expression. No significant differences in the incidences of good and poor response results were found for patients with Hodgkin's disease versus non-Hodgkin's lymphoma, with stage I-II versus stage III-IV, with age >40 versus age less than or equal to40 years, or with B symptoms versus without B symptoms. Tc-TF scan results, which may represent either Pgp or MRP expression, accurately predict chemotherapy response in patients with ML.
關聯:	ONCOLOGY REPORTS 9(2):247-251
显示于类别:	[台中附設醫院] 期刊論文

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