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http://ir.cmu.edu.tw/ir/handle/310903500/30154
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| 題名: | Antioxidative and hypolipidemic effects of barley leaf essence in a rabbit model of atherosclerosis |
| 作者: | Yu, YM;Wu, CH;Tseng, YH;Tsai, CME;Chang, WC |
| 貢獻者: | 醫學院醫學系;China Med Coll, Sch Med, Dept Nutr, Taichung, Taiwan;China Med Coll, Sch Med, Dept Pharmacol, Taichung, Taiwan;China Med Coll, Sch Med, Dept Physiol, Taichung, Taiwan;Fu Jen Catholic Univ, Dept Nutr & Food Sci, Taipei, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 14:50:14 (UTC+8) |
| 出版者: | JAPANESE PHARMACOLOGICAL SOC |
| 摘要: | Humic acid (HA) has been proposed as factor in the cause of Blackfoot disease (BFD) among individuals who live along the southwest coast of Taiwan. In this study, the interaction of the synthetic humic acid, made from catechol, with sodium arsenate (As(V)) was investigated and assessed wit respect to damage to human red blood cells. HA is characterized as phenolic and phenolic carboxylic polymer structures containing both -COOH and -OH as their main functional groups. HA and As(V) alone are able to hemolyze 60-100 and 5-20% human red blood cells at concentrations of 50-300 mug/ml and 5-100 mM, respectively, after 6 h. HA is shown to be relatively ineffective in causing ATP depletion of red blood cells. For organometallic complexes composed of HA-As(V) the inhibition effect of EDTA was completely abolished and the use of the triple complex HA-As(V)-EDTA resulted in an enhancement of hemolysis. HA caused lipid peroxidation in a concentration- and time-dependent manner. However, HA-As(V) and As(V) decreased lipid peroxidation. These results indicated that HA initiates oxidative stress on red blood cells and this results in their dysfunction. HA-chelated high-concentration metal complexes inhibited the structures containing the main functional groups involved in decreasing hemolysis, and, thus, HA may be a significant factor in the etiology of BFD. (C) 2002 Elsevier Science (USA). |
| 關聯: | JAPANESE JOURNAL OF PHARMACOLOGY 89(2):142-148 |
| 顯示於類別: | [醫學系] 期刊論文
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