Humic acid induces the generation of nitric oxide in human umbilical vein endothelial cells: Stimulation of nitric oxide synthase during cell injury

CMUR > College of Health Care > Graduate Institute of Nutrition > Journal articles > Item 310903500/29413

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/29413

Title:	Humic acid induces the generation of nitric oxide in human umbilical vein endothelial cells: Stimulation of nitric oxide synthase during cell injury
Authors:	Hseu, YC;Wang, SY;Chen, HY;Lu, FJ;Gau, RJ;Chang, WC;Liu, TZ;Yang, HL
Contributors:	健康照護學院營養系;China Med Coll, Dept Nutr, Taichung 40421, Taiwan;China Med Coll, Sch Med, Dept Physiol, Taichung 40421, Taiwan;Fooyin Inst Technol, Dept Med Technol, Kaohsiung, Taiwan;Natl Taiwan Univ, Coll Med, Dept Biochem, Taipei 10018, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:34:05 (UTC+8)
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Abstract:	BACKGROUND. The diagnostic accuracy of technetium-99m methoxyisobutylisonitrile (Tc-MIBI) single photon emission computed tomography (SPECT) and computed tomography (CT) of the head and neck for differentiating recurrent or residual nasopharyngeal carcinomas (NPC) from benign lesions after radiotherapy was compared with positron emission tomography (PET) with 18-fluoro-2-deoxyglucose (FDG). METHODS. Thirty six NPC patients underwent head and neck CT, Tc-MIBI SPECT, and FDG-PET four months after radiotherapy to differentiate recurrent or residual NPC from benign lesions. Histopathologic examinations of nasopharyngeal biopsies were performed for all 36 patients. No patients had multiple foci of NPC. RESULTS. Based on biopsy results, the sensitivity, specificity, and accuracy of CT for differentiating recurrent or residual NPC from benign lesions were 73%, 88%, and 83%, respectively. The sensitivity, specificity, and accuracy of Tc-MIBI SPECT were 73%, 96%, and 89%, respectively. The sensitivity, specificity, and accuracy of FDG-PET were 100%, 96%, and 97%, respectively. Combination CT and Tc-MIBI SPECT for 28 NPC patients with congruent results showed the same sensitivity, specificity, and accuracy of 100%, 96%, and 96%, respectively, as FDG-PET for differentiating recurrent or residual NPC from benign lesions. In eight patients with incongruent results between CT and Tc-MIBI SPECT, FDG-PET correctly differentiated two benign lesions and six recurrent or residual NPCs. CONCLUSIONS. In detecting recurrent or residual NPC, FDG-PET is the best tool. However, combined use of CT and Tc-MIBI SPECT can result in the same accuracy as FDG-PET.
Relation:	FREE RADICAL BIOLOGY AND MEDICINE 32(7):619-629
Appears in Collections:	[Graduate Institute of Nutrition ] Journal articles

Files in This Item:

There are no files associated with this item.

Loading...