UCN-01 suppresses E2F-1 mediated by ubiquitin-proteasome-dependent degradation

CMUR > China Medical University Hospital > Jurnal articles > Item 310903500/29052

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/29052

Title:	UCN-01 suppresses E2F-1 mediated by ubiquitin-proteasome-dependent degradation
Authors:	Hsueh, CT;Wu, YC;Schwartz, GK
Contributors:	附設醫院內科部血液腫瘤科;China Med Coll Hosp, Dept Internal Med, Div Hematol Oncol, Taichung, Taiwan;Vet Gen Hosp, Dept Surg, Div Thorac Surg, Taipei 11217, Taiwan;Natl Yang Ming Med Coll, Taipei 11221, Taiwan;Mem Sloan Kettering Canc Ctr, Dept Med, Div Solid Tumor Oncol, Gastrointestinal Oncol Res Lab, New York, NY 10021 USA
Date:	2001
Issue Date:	2010-09-24 14:19:58 (UTC+8)
Publisher:	AMER ASSOC CANCER RESEARCH
Abstract:	Objectives To assess vascular impedance at three different locations in the middle cerebral artery (MCA) in normal fetuses throughout gestation. Materials and methods Uncomplicated singleton pregnancies at 15-40 weeks' gestation in which Doppler surveys of both MCAs could be obtained were recruited. The pulsatility index (PI) and resistance index (RI) of the proximal, mid and distill sites of both MCAs were measured. The five gestation periods at which the Doppler surveys were performed were (i) 15-19 completed weeks; (ii) 20-24 completed weeks; (iii) 25-29 completed weeks; (iv) 30-34 completed weeks; (v) 35-39 completed weeks. Results A total of 42 fetuses were recruited. The average PI/RI values of the proximal, mid and distal MCA were 1.61/0.82, 1.77/0.82, and 1.84/0.84, respectively. The PI value of the proximal MCA was lower than that of the mid and distal MCA. The PI values of the mid and distal MCA showed no difference. The RI value of the MCA from the three locations also showed no difference. The PI/RI values of MCA for each gestational phase were: (i) 1.81/0.87; (ii) 1.79/0.86; (iii) 1.78/0.86; (iv) 1.70/0.81; (v) 1.62/0.77, respectively. Decreased PI/RI values were observed after 30 weeks' gestation. Conclusions The PI values of the proximal MCA are lower than those of the mid and distal MCA. A marked decrease in PI/RI values was observed after 30 weeks' gestation.
Relation:	CLINICAL CANCER RESEARCH 7(3):669-674
Appears in Collections:	[China Medical University Hospital] Jurnal articles

Files in This Item:

There are no files associated with this item.

Loading...