Cefepime MIC as a predictor of the extended-spectrum beta-lactamase type in Klebsiella pneumoniae, Taiwan

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Title:	Cefepime MIC as a predictor of the extended-spectrum beta-lactamase type in Klebsiella pneumoniae, Taiwan
Authors:	Yu, WL;Pfaller, MA;Winokur, PL;Jones, RN
Contributors:	附設醫院;China Med Coll Hosp, Taichung, Taiwan;Univ Iowa, Coll Med, Iowa City, IA USA;JONES Grp, JMI Labs, N Liberty, IA 52317 USA;Tufts Univ, Sch Med, Boston, MA 02111 USA
Date:	2002
Issue Date:	2010-09-24 14:17:03 (UTC+8)
Publisher:	CENTER DISEASE CONTROL
Abstract:	Background: The effects of supplementation of young barley leaf extract (BL) and/or antioxidative vitamins C and E on different low-density lipoprotein (LDL) subfractions susceptibility to oxidation and free radical scavenging activities in patients with type 2 diabetes were evaluated. Methods: Thirty-six type 2 diabetic patients were enrolled in this study. The subjects received one of the following supplements daily for 4 weeks: 15 g BL, 200 mg vitamin C and 200 mg vitamin E (CE), or BL plus CE (BL+CE). Results: The lucigenin-chemiluminescence (CL) and luminol-CL levels in blood were significantly reduced in all groups. Vitamin E content of LDL subfractions increased significantly following supplements, especially for BL+CE group. The percent increase of lag times in the BL+CE was significantly higher than those in the BL or CE group. The antioxidative effect of BL+CE was the greatest for small, dense LDL (Sd-LDL) with further increases in percentage of lag times 4 folds compared to BL alone. Conclusion: Our results indicate that supplementation with BL may help to scavenge oxygen free radicals, save the LDL-vitamin E content, and inhibit LDL oxidation. Furthermore,the addition of vitamins C and E to BL can inhibit the Sd-LDL oxidation more effectively, which may protect against vascular diseases in type 2 diabetic patients.
Relation:	EMERGING INFECTIOUS DISEASES 8(5):522-524
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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