中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/25362
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    题名: Invasive pattern grading score designed as an independent prognostic indicator in oral squamous cell carcinoma
    作者: 張雲晶(Yun-Ching Chang);聶鑫(Shin Nieh)*;陳素鳳(Chen, Su Feng)*;饒樹文(Shu-Wen Jao);林育儒(Yu-Lu Lin);傅锷(Earl Fu)
    贡献者: 口腔衛生學系
    关键词: clinical parameters;independent prognostic indicator;invasive pattern grading score;oral squamous;cell carcinoma
    日期: 2010-07
    上传时间: 2010-08-24 13:09:47 (UTC+8)
    摘要: Aims: To test the validity of an invasive pattern
    grading score (IPGS) developed for oral squamous cell
    carcinoma (OSCC) as a prognostic indicator and to
    elucidate the relationship between the IPGS and
    clinical parameters.
    Methods and results: The IPGS was applied to a total of
    153 cases of OSCC. There were significant correlations
    between IPGS and distant metastasis (P = 0.01) or
    recurrence (P = 0.001). However, there were no significant
    correlations between IPGS and gender, age,
    size or extent, location, status of lymph node metastasis,
    clinical staging, or histological grading. Cases of
    OSCC with higher IPGS were associated with poor
    patient survival (P < 0.001) and higher probability of
    tumour recurrence (P = 0.001). Intraobserver (j =
    0.74) and interobserver agreement (j = 0.67) were
    very satisfactory.
    Conclusions: Our study confirms the validity of the
    IPGS, an indicator that is simple and easy to use. IPGS
    not only provides histological assessment of biological
    behaviour, but also offers an independent prognostic
    factor that may influence the treatment of OSCC.
    關聯: HISTOPATHOLOGY 58(1):1~9
    显示于类别:[口腔衛生學系] 期刊論文

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